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Molecular mechanism of UDCA response. (A) GO analysis via GSEA; (B) The most significantly altered GO terms; (C) SYK expression between the high-risk and low-risk PBC patients; (D) The <t>ROC</t> <t>curve</t> analysis of SYK; (E) Identification of hub genes; Infiltration analysis of resting memory CD4 T cells (F) and monocytes (G) ; (H) Correlation between SYK expression and monocyte proportion.
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Molecular mechanism of UDCA response. (A) GO analysis via GSEA; (B) The most significantly altered GO terms; (C) SYK expression between the high-risk and low-risk PBC patients; (D) The <t>ROC</t> <t>curve</t> analysis of SYK; (E) Identification of hub genes; Infiltration analysis of resting memory CD4 T cells (F) and monocytes (G) ; (H) Correlation between SYK expression and monocyte proportion.
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Molecular mechanism of UDCA response. (A) GO analysis via GSEA; (B) The most significantly altered GO terms; (C) SYK expression between the high-risk and low-risk PBC patients; (D) The <t>ROC</t> <t>curve</t> analysis of SYK; (E) Identification of hub genes; Infiltration analysis of resting memory CD4 T cells (F) and monocytes (G) ; (H) Correlation between SYK expression and monocyte proportion.
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Molecular mechanism of UDCA response. (A) GO analysis via GSEA; (B) The most significantly altered GO terms; (C) SYK expression between the high-risk and low-risk PBC patients; (D) The <t>ROC</t> <t>curve</t> analysis of SYK; (E) Identification of hub genes; Infiltration analysis of resting memory CD4 T cells (F) and monocytes (G) ; (H) Correlation between SYK expression and monocyte proportion.
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Molecular mechanism of UDCA response. (A) GO analysis via GSEA; (B) The most significantly altered GO terms; (C) SYK expression between the high-risk and low-risk PBC patients; (D) The <t>ROC</t> <t>curve</t> analysis of SYK; (E) Identification of hub genes; Infiltration analysis of resting memory CD4 T cells (F) and monocytes (G) ; (H) Correlation between SYK expression and monocyte proportion.
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Molecular mechanism of UDCA response. (A) GO analysis via GSEA; (B) The most significantly altered GO terms; (C) SYK expression between the high-risk and low-risk PBC patients; (D) The ROC curve analysis of SYK; (E) Identification of hub genes; Infiltration analysis of resting memory CD4 T cells (F) and monocytes (G) ; (H) Correlation between SYK expression and monocyte proportion.

Journal: Frontiers in Pharmacology

Article Title: Uncovering key molecules and immune landscape in cholestatic liver injury: implications for pathogenesis and drug therapy

doi: 10.3389/fphar.2023.1171512

Figure Lengend Snippet: Molecular mechanism of UDCA response. (A) GO analysis via GSEA; (B) The most significantly altered GO terms; (C) SYK expression between the high-risk and low-risk PBC patients; (D) The ROC curve analysis of SYK; (E) Identification of hub genes; Infiltration analysis of resting memory CD4 T cells (F) and monocytes (G) ; (H) Correlation between SYK expression and monocyte proportion.

Article Snippet: The bar charts and the ROC curve analysis were completed by GraphPad Prism 8.0 (California, United States). p < 0.05 was considered statistically significant.

Techniques: Expressing